Free Radical Reaction of 4-Nitroquinoline 1-Oxide
نویسندگان
چکیده
منابع مشابه
Spectrophotomatic Assay for the Enzyme Catalyzed Reaction of 4-nitroquinoline 1-oxide with Glutathione
4-Nitroquinoline 1-oxide (4NQO( is a toxic and carcinogenic compound that has been reported to be subject to conjugation with glutathione (GSH). This reaction may proceed non-enzymatically or be catalyzed by GSH transferases. The non-enzymatic rate for this reaction has been reported to be very high. The purposes of this investigation were todevelop a spectrophotometric assay for the reaction o...
متن کاملReduction of 4-nitroquinoline 1-oxide to 4-hydroxyaminoquinoline 1-oxide in lysates of cytomegalovirus-infected cells.
The rates of virus inactivation by 4-nitroquinoline 1-oxide (NQO) and 4-hydroxyaminoquinoline 1-oxide (HAQO) were compared and samples of cytomegalovirus (CMV)-infected cell lysates to which NQO had been added were examined for the presence of HAQO. These experiments demonstrated that (i) CMV inactivation by HAQO was more rapid than with NQO, (ii) virus inactivation by either NQO or HAQO failed...
متن کاملSensitivity of Repair-deficient Mutants and Similar Mutants to 4-Nitroquinoline 1-Oxide, 4-Nitropyridine 1-Oxide, and Their Derivativesl
also tested. 4-Nitroquinoline 1-oxide, 4-hydroxyaminoquinoline 1oxide, 3-methyl-4-nitropyridine 1-oxide, and 2,3-dimethyl-4nitropyridine 1-oxide caused wider growth-inhibiting zones with mutants of Escherichia coli, such as the DNA polymerase 1-deficient mutant, po/Al, and the recombination-deficient mutants, r<?cA13 and recB21, than with the wild strain. These compounds also caused wider growt...
متن کاملSensitivity of repair-deficient mutants and similar mutants to 4-nitroquinoline 1-oxide, 4-nitropyridine 1-oxide, and their derivatives.
also tested. 4-Nitroquinoline 1-oxide, 4-hydroxyaminoquinoline 1oxide, 3-methyl-4-nitropyridine 1-oxide, and 2,3-dimethyl-4nitropyridine 1-oxide caused wider growth-inhibiting zones with mutants of Escherichia coli, such as the DNA polymerase 1-deficient mutant, po/Al, and the recombination-deficient mutants, r<?cA13 and recB21, than with the wild strain. These compounds also caused wider growt...
متن کاملIn-vivo Antioxidant Effects of Ethyl Acetate Fraction of Mentha spicata L. on 4-Nitroquinoline-1-Oxide Injected Mice
Antioxidant effects of ethyl acetate fraction of Mentha spicata (L.) were evaluated against 4-nitroquinoline-1-oxide injected mice. For this study, experiment setup consisted of 36 albino mice of either sex divided into 6 groups: Control (25% DMSO in water), ethyl acetate fraction (EAF) alone group (80, 160 mg/Kg body weight-bwt), 4-NQO (7.5 mg/Kg bwt-IP) alone and 4-NQO + EAF. EAF and vehicles...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1965
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.85.1_66